Bullous pemphigoid is an autoimmune skin disease.

It occurs in the elderly population over 60 years of age*.

Clinically, tense blisters (called bullae) are present and can be preceded by urticaria-like lesions. Itching which can be intense is usually present.

It is characterized histologically by subepidermal splits. Direct immunofluoresence of the normal appearing skin may show IgG and complement C3 deposits in the basement membrane area.

-Treatment options include topical and systemic steroids, immunomodulators and biologicals (Rituximab or anti CD-20)


* Other bullous pemphigoid forms can be found during pregnancy (pemphigoid gestationis) and can produce scarring. (cicatricial pemphigoid)