Bullous pemphigoid is an autoimmune skin disease.

It occurs in the elderly population over 60 years of age*.

Clinically, tense blisters (called bullae) are present and can be preceded by urticaria-like lesions. Itching which can be intense is usually present.
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It is characterized histologically by subepidermal splits. Direct immunofluoresence of the normal appearing skin may show IgG and complement C3 deposits in the basement membrane area.

-Treatment options include topical and systemic steroids, immunomodulators and biologicals (Rituximab or anti CD-20)

 

* Other bullous pemphigoid forms can be found during pregnancy (pemphigoid gestationis) and can produce scarring. (cicatricial pemphigoid)