-Psoriasis is a common skin condition which affects about 2% of the population.
It is more frequent in Caucasians of northern European origin.

 

-Its classical (vulgaris) presentation consists of pinkish-erythematous and scaly plaques located on the extensor areas such as the elbows, knees buttocks and the scalp.

-Old lesions can sometimes show lesions (Koebner phenomenon)

-The disease is classically non itchy however in up to a third of cases, scratching is a common complaint.

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It is sometimes associated with a change of the tongue: geographic tongue

-Scraping of the lesions produces pinpoint bleeding (Auspitz sign).

-Nail changes are usually also found (irregular nail pitting, onycholysis, “oil spot”, rough surface)

 

-Other forms are called inverse psoriasis, guttate psoriasis, and palmoplantar psoriasis

-Causes are partially known and genetic factors only explain part of the problem. Indeed in monozygotic twins, if one is affected, the other twin is only affected in 70% of the cases.

-Psoriasis is described as been associated with the metabolic syndrome which includes hypertension, obesity, diabetes and hyperlipideamia.

 

Treatment options include:

-topical steroids

-oral

a. acitretin

b. methotrexate

c. ciclosporin

d. apremilast
-phototherapy

 

-biologics:
a. Infliximab (Remicade®)
b. Bimekizumab (Bimzelx®)
c. Etanercept (Enbrel®)
d. Adalimumab (Humira®)
e. Ustekinumab (Stelara®)
f. Secukinumab (Cosentyx®)
g. Ixekizumab (Taltz®)
h. Brodalumab (Siliq®)
i. Guselkumab (Tremfya®)
j. Tildrakizumab (Ilumya®)
k. Risankizumab (Skyrizi®)…