Introduction

Historical Features

Epidemiology

 

 

Clinical Features

Clinical Presentation

Differential diagnosis on clinical grounds

 

 

Dermatoscopical Features

Differential Diagnosis on dermoscopical grounds

 

 

Histological Features

 

 

Association of Seborrheic Keratosis (SK) with systemic disease

 

 

Etiology

Origin of SK

  • -follicular epithelium
  • -solar lentigo

 

 

Causal factors

  • -UV exposure
  • -HPV infection (Human papillomavirus))
  • -deficiency in presenilin
  • -vitamin A deficiency

 

Suggested Mechanisms of growth

By hyperproliferation theory

Accumulation of senescent cells theory

 

 

Authors’ Experience

 

 

Conclusion

 

 

Pigmentation in SK: a mechanism explained by parallelism?

 

 

Treatment

 

 

This review was initially written in 2005 and does not include new discoveries like the proposed fgf3 receptor mutation. However, the information is correct and the publications which came out at later dates do not answer in a definite way the questions made by the study of this frequent albeit enigmatic lesion.

This advice is for informational purposes  only and does not replace therapeutic judgement done by a skin doctor.