Pathophysiology and new therapies in Atopic Dermatitis


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Atopic dermatitis (AD) is a chronic non-communicable relapsing skin disease. Globally, it is highly prevalent affecting young children, teenagers and adults. A genetic predisposition combined with environmental trigger factors attributes to this severely pruritic eczema. The pathophysiology includes upregulation of cytokines, chemokines, proteases, neuropeptides and other mediators suggesting an involvement of the autonomic/sensory nervous system in the pathophysiology which contributes to pruritus, pain as well as immunodysregulation and skin barrier dysfunction. Despite that. AD can be now seen as a flare that itches, because – similar to rheumatoid arthritis, which is an inflammation with symptom of pain – a dysregulated immune system, including neuroimmune system, results in the perpet