The pathogenesis of vitiligo and schizophrenia has not been adequately clarified. This article explores the role of lipids in these diseases. Both conditions have been associated with stress in several observations and studies. Research data indicate complex interactions between oxidative stress and metabolic syndrome–with lipid
abnormalities being a significant component of the latter–in these diseases. The impaired membrane lipid homeostasis mechanism is related to the increased phospholipid remodeling caused by excessive oxidative stress in schizophrenia. We indicate that sphingomyelin is possibly involved in the pathogenesis of these diseases.
Statins have anti-inflammatory and immunomodulating effects and an effect against oxidative stress. Preliminary clinical studies show that these agents may be beneficial in vitiligo and schizophrenia, but their therapeutic value should be studied further. Studies looking into symptom severity and cognition in schizophrenia patients after statin
therapy are required.